Acute sickle cell syndromes in Nigerian adults
Identifieur interne : 002578 ( Main/Exploration ); précédent : 002577; suivant : 002579Acute sickle cell syndromes in Nigerian adults
Auteurs : M. O. Ibidapo [Nigeria] ; O. O. Akinyanju [Nigeria]Source :
- Clinical & Laboratory Haematology [ 0141-9854 ] ; 2000-06.
English descriptors
- Teeft :
- Acute admissions, Acute chest syndrome, Acute illness, Akinyanju, Akinyanju johnson, American journal, Anaemia, Anaemia crises, Anaemia crisis, Bacterial infection, Bacterial infections, Blackwell science, Blood cultures, Brozovic, Cell syndromes, Clinical manifestations, Clinical signs, Dacie lewis, Davies brownwell, Davies henthorn, Emergency unit, Girdle syndrome, Haemoglobin concentration, Hendrickse collard, High mortality rate, Higher incidence, Jellife humphreys, Lagos, Malaria, Mallouh salamah, Nigeria, Nigerian, Nigerian children, Pain crises, Pain crisis, Present patients, Same hospital, Sickle, Sickle cell anaemia, Sickle cell anemia, Sickle cell crises, Sickle cell disease, Sickle cell trait, Sickle gene, Syndrome, Tropical medicine, Tropical paediatrics, Uncomplicated pain crisis, Undetermined origin, Walters lehmann, Younger patients.
Abstract
The pattern of acute illness was determined in 102 adolescents and adults with sickle cell anaemia who presented to the emergency unit of a Lagos hospital. The patients had a mean age of 20.5 years ( sd 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (P < 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. The Girdle pain crisis more frequently resulted in a fatal outcome than the uncomplicated bone pain crisis.
Url:
DOI: 10.1046/j.1365-2257.2000.00292.x
Affiliations:
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Akinyanju</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, College of Medicine of the University of Lagos, Lagos</wicri:regionArea><wicri:noRegion>Lagos</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical & Laboratory Haematology</title><title level="j" type="alt">CLINICAL AND LABORATORY HAEMATOLOGY</title><idno type="ISSN">0141-9854</idno><idno type="eISSN">1365-2257</idno><imprint><biblScope unit="vol">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="151">151</biblScope><biblScope unit="page" to="155">155</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Science Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2000-06">2000-06</date></imprint><idno type="ISSN">0141-9854</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0141-9854</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute admissions</term><term>Acute chest syndrome</term><term>Acute illness</term><term>Akinyanju</term><term>Akinyanju johnson</term><term>American journal</term><term>Anaemia</term><term>Anaemia crises</term><term>Anaemia crisis</term><term>Bacterial infection</term><term>Bacterial infections</term><term>Blackwell science</term><term>Blood cultures</term><term>Brozovic</term><term>Cell syndromes</term><term>Clinical manifestations</term><term>Clinical signs</term><term>Dacie lewis</term><term>Davies brownwell</term><term>Davies henthorn</term><term>Emergency unit</term><term>Girdle syndrome</term><term>Haemoglobin concentration</term><term>Hendrickse collard</term><term>High mortality rate</term><term>Higher incidence</term><term>Jellife humphreys</term><term>Lagos</term><term>Malaria</term><term>Mallouh salamah</term><term>Nigeria</term><term>Nigerian</term><term>Nigerian children</term><term>Pain crises</term><term>Pain crisis</term><term>Present patients</term><term>Same hospital</term><term>Sickle</term><term>Sickle cell anaemia</term><term>Sickle cell anemia</term><term>Sickle cell crises</term><term>Sickle cell disease</term><term>Sickle cell trait</term><term>Sickle gene</term><term>Syndrome</term><term>Tropical medicine</term><term>Tropical paediatrics</term><term>Uncomplicated pain crisis</term><term>Undetermined origin</term><term>Walters lehmann</term><term>Younger patients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pattern of acute illness was determined in 102 adolescents and adults with sickle cell anaemia who presented to the emergency unit of a Lagos hospital. The patients had a mean age of 20.5 years ( sd 13.1) and a male–female ratio of 1.5. The symptoms included fever (72%), fatigue and weakness (59%), anorexia (59%) and pain (57.5%) while major clinical signs were pallor (100%), jaundice (71%) and hepatomegaly (68%). Sixty‐eight per cent of patients had sickle cell crises, including one with hemiplegic stroke, 10% with combined anaemia and pain crises, 33% with anaemia crises only and 23.5% with pain crises only. Sixty‐three per cent had infection which was malaria in 24.5%, bacterial in 17% and viral in 6%. Of 16 patients with pyrexia of unknown origin, seven responded to treatment with chloroquine and eight to antibiotics. Infection was detected in 50% of the patients with sickle cell crises. The association between anaemia crises and malaria was significant (P < 0.05). Of the eight deaths, seven (88%) had anaemia crises. In contrast to studies conducted two decades ago in the same hospital, the prevalence of anaemia crises now exceeds that of pain crises and malaria now exceeds that of bacterial infection. Severe symptomatic anaemia (anaemia crisis) was more frequently associated with infection (mostly malaria) than was bone pain crisis. The Girdle pain crisis more frequently resulted in a fatal outcome than the uncomplicated bone pain crisis.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Ibidapo, M O" sort="Ibidapo, M O" uniqKey="Ibidapo M" first="M. O." last="Ibidapo">M. O. Ibidapo</name></noRegion><name sortKey="Akinyanju, O O" sort="Akinyanju, O O" uniqKey="Akinyanju O" first="O. O." last="Akinyanju">O. O. Akinyanju</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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